Full Product Name
MLNR Antibody (C-term)
Product Synonym Names
Motilin receptor; G-protein coupled receptor 38; MLNR; GPR38; MTLR; MTLR1
Product Gene Name
anti-MLNR antibody
[Similar Products]
Antibody/Peptide Pairs
MLNR peptide (MBS9219318) is used for blocking the activity of MLNR antibody (MBS9202840)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
357-386
3D Structure
ModBase 3D Structure for O43193
Specificity
This MLNR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 357-386 amino acids from the C-terminal region of human MLNR.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-MLNR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MLNR antibody
MLNR is a receptor for motilin.
Product Categories/Family for anti-MLNR antibody
Neuroscience; Signal Transduction; GPCR Antibodies
Applications Tested/Suitable for anti-MLNR antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-MLNR antibody
WB~~1:1000
Western Blot (WB) of anti-MLNR antibody
MLNR Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the MLNR antibody detected the MLNR protein (arrow).
Immunohistochemistry (IHC) of anti-MLNR antibody
MLNR Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MLNR Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
NCBI/Uniprot data below describe general gene information for MLNR. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001498.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001507.1
[Other Products]
UniProt Primary Accession #
O43193
[Other Products]
UniProt Related Accession #
O43193[Other Products]
NCBI Official Full Name
motilin receptor
NCBI Official Synonym Full Names
motilin receptor
NCBI Official Symbol
MLNR??[Similar Products]
NCBI Official Synonym Symbols
GPR38; MTLR1
??[Similar Products]
NCBI Protein Information
motilin receptor
UniProt Protein Name
Motilin receptor
UniProt Synonym Protein Names
G-protein coupled receptor 38
Protein Family
Motilin receptor
UniProt Gene Name
MLNR??[Similar Products]
UniProt Synonym Gene Names
GPR38; MTLR; MTLR1??[Similar Products]
UniProt Entry Name
MTLR_HUMAN
NCBI Summary for MLNR
Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract. The protein encoded by this gene is a motilin receptor which is a member of the G-protein coupled receptor 1 family. This member is a multi-pass transmembrane protein, and is an important therapeutic target for the treatment of hypomotility disorders. [provided by RefSeq, Aug 2011]
UniProt Comments for MLNR
MLNR: Receptor for motilin. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 13q14-q21
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity; growth hormone-releasing hormone receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; digestion
Product References and Citations for anti-MLNR antibody
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
Mitselos, A., et al. Peptides 29(7):1167-1175(2008)
Ter Beek, W.P., et al. Inflamm. Bowel Dis. 14(5):612-619(2008)
Tokunaga, H., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 294 (2), G460-G466 (2008) :
Dowal, L., et al. J. Biol. Chem. 281(33):23999-24014(2006)
Research Articles on MLNR
1. data support important roles of new regions in the TM domains of the motilin receptor for erythromycin action, suggesting differential mechanisms of actions by peptidyl and non-peptidyl ligands
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
