Low affinity immunoglobulin gamma Fc region receptor II-c; IgG Fc receptor II-c; CDw32; Fc-gamma RII-c; Fc-gamma-RIIc; FcRII-c; CD32; FCGR2C; CD32; FCG2; IGFR2

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This FCGR2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-307 amino acids from the C-terminal region of human FCGR2C.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-FCGR2C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

FCGR2C is the receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. It is involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.

Immunology; Signal Transduction

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)

WB~~1:1000

Western blot analysis of FCGR2C Antibody (C-term) in mouse brain tissue lysates (35ug/lane).FCGR2C (arrow) was detected using the purified Pab.

Formalin-fixed and paraffin-embedded human lung carcinoma reacted with FCGR2C Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

35578

Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)

low affinity immunoglobulin gamma Fc region receptor II-c

Low affinity immunoglobulin gamma Fc region receptor II-c

CD32; FCG2; IGFR2; IgG Fc receptor II-c; Fc-gamma-RIIc; FcRII-c??[Similar Products]

FCG2C_HUMAN

This gene encodes one of three members of a family of low-affinity immunoglobulin gamma Fc receptors found on the surface of many immune response cells. The encoded protein is a transmembrane glycoprotein and may be involved in phagocytosis and clearing of immune complexes. An allelic polymorphism in this gene results in both coding and non-coding variants. [provided by RefSeq, Apr 2012]

FCGR2C: a transmembrane receptor for the Fc region of complexed or aggregated immunoglobulin gamma (IgG). Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down modulation of previous state of cell activation triggered via antigen receptors on B cells, T cells or via another Fc receptor. Three splice-variant isoforms have been observed.

Protein type: Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: cytoplasm; integral to membrane; plasma membrane

Molecular Function: protein binding; transmembrane receptor activity; IgG binding

Biological Process: immune response; signal transduction

Disease: Thrombocytopenic Purpura, Autoimmune

Metes D., et.al., Blood 91:2369-2380(1998).
Stuart S.G.,et.al., EMBO J. 8:3657-3666(1989).

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