Full Product Name
MYL2 Polyclonal Antibody
Product Synonym Names
Myosin regulatory light chain 2; ventricular/cardiac muscle isoform (MLC-2) (MLC-2v)
Product Gene Name
anti-MYL2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P10916
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/mL (lot specific)
Immunogen
Synthesized peptide derived from human MYL2
Buffer
PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol pH 7.4.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-MYL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MYL2 antibody
Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.
Applications Tested/Suitable for anti-MYL2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-MYL2 antibody
WB: 1:500-2000
ELISA: 1:10000-20000
Western Blot (WB) of anti-MYL2 antibody
Western Blot analysis of 1) Mouse heart, 2) Hela using MYL2 Polyclonal Antibody at dilution of 1:500.
NCBI/Uniprot data below describe general gene information for MYL2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000423.2
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NCBI GenBank Nucleotide #
NM_000432.3
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UniProt Primary Accession #
P10916
[Other Products]
UniProt Secondary Accession #
Q16123[Other Products]
UniProt Related Accession #
P10916[Other Products]
NCBI Official Full Name
myosin regulatory light chain 2, ventricular/cardiac muscle isoform
NCBI Official Synonym Full Names
myosin light chain 2
NCBI Official Symbol
MYL2??[Similar Products]
NCBI Official Synonym Symbols
MLC2; CMH10; MLC-2s/v
??[Similar Products]
NCBI Protein Information
myosin regulatory light chain 2, ventricular/cardiac muscle isoform
UniProt Protein Name
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
UniProt Synonym Protein Names
Cardiac myosin light chain 2
Protein Family
Myosin regulatory
UniProt Gene Name
MYL2??[Similar Products]
UniProt Synonym Gene Names
MLC-2s/v??[Similar Products]
NCBI Summary for MYL2
Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
UniProt Comments for MYL2
MRLC2V: myosin regulatory light chain 2, ventricular/cardiac muscle isoform. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.
Protein type: Contractile
Chromosomal Location of Human Ortholog: 12q24.11
Cellular Component: A band; actin cytoskeleton; cytoskeleton; cytosol; myofibril; myosin complex; sarcomere
Molecular Function: actin monomer binding; calcium ion binding; myosin heavy chain binding; protein binding; structural constituent of muscle
Biological Process: cardiac muscle contraction; cardiac myofibril assembly; heart contraction; heart development; muscle cell fate specification; muscle fiber development; muscle filament sliding; negative regulation of cell growth; positive regulation of the force of heart contraction; post-embryonic development; regulation of striated muscle contraction; regulation of the force of heart contraction; ventricular cardiac muscle tissue morphogenesis
Disease: Cardiomyopathy, Familial Hypertrophic, 10
Research Articles on MYL2
1. NKX2-5 and MLC2v double-positive cells possess ventricular-like properties. The results demonstrate that the NKX2-5(eGFP/w) and MLC2v(mCherry/w) hPSCs provide a powerful model system to capture region-specific cardiac differentiation from early to late stages. Our study would facilitate subtype-specific cardiac development and functional analysis using the hPSC-derived sources.
Precautions
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Disclaimer
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