Product Name
C1orf124, cDNA Clone
Full Product Name
C1orf124 cDNA Clone
Product Gene Name
C1orf124 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggatgatg acttgatgtt ggcactgcgg cttcaggagg agtggaactt gcaggaggcg gagcgcgatc atgcccagga gtccctgtcg ctagtggacg cgtcgtggga gttggtggac cccacaccgg acttgcaggc actgtttgtt cagtttaacg accaattctt ctggggccag ctggaggccg tcgaggtgaa gtggagcgtg cgaatgaccc tgtgtgctgg gatatgcagc tatgaaggga agggtggaat gtgttccatc cgtctcagcg aacccctttt gaagttgagg ccaagaaagg atcttgtaga gaccctcctg catgaaatga tacatgccta tttatttgtc actaataacg acaaagaccg agaagggcat ggtccagaat tttgtaaaca tatgcatcgc atcaacagcc tgactggagc caatataacg gtataccata cttttcacga tgaggtggat gagtatcggc gacactggtg gcgctgcaat gggccgtgcc agcacaggcc accgtattac ggctatgtca aacgagctac taacagggaa ccctctgctc atgactattg gtgggctgag caccagaaaa cctgtggagg cacttacata aaaatcaagg aaccagagaa ttactcaaaa aaaggcaaag gaaaggcaaa actaggaaag gaaccagtat tggccgcaga gaataaagat aaacccaaca gaggtgaggc ccagctagta atccctttta gtgggaaagg atatgttcta ggagaaacaa gcaatttacc ttcacctggg aaactgatca cttcacatgc cattaataaa acccaagatc ttttaaatca aaaccattca gcaaatgctg taagacttaa ttctaaaatc aaggtgaaat ttgaacagaa tggttcaagt aaaaattctc atctggtctc ccctgctgtt agtaacagtc accaaaatgt tctaagcaac tactttccta gagtatcatt tgccaaccaa aaggctttca gaggtgtgaa tggatctcca aggataagtg taacagttgg caacatccct aaaaactcag tctcttctag ttctcagaga agggtttcat cttctaagat atccctaaga aattcttcaa aagtaacgga atcagcatct gtgatgccat cccaggatgt gagtgggtct gaagatacat tcccaaataa acgacctagg ctagaagata agactgtttt tgacaatttt tttatcaaga aagagcaaat aaaaagcagt ggtaatgatc caaagtatag tacaaccaca gctcagaatt ccagcagttc atccagtcag agcaaaatgg ttaattgccc agtttgtcag aatgaagttc tggagtctca gattaatgag cacttggact ggtgccttga aggtgacagc atcaaagtca aaagcgaaga aagtctttga
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of C1orf124 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for C1orf124. It may not necessarily be applicable to this product.
NCBI Accession #
BC068478
[Other Products]
UniProt Secondary Accession #
Q5TE78; Q6UWW6; Q96BC5; Q96KA0; B1AKT0; B5MEF7[Other Products]
UniProt Related Accession #
Q9H040[Other Products]
Molecular Weight
24,247 Da
NCBI Official Full Name
Homo sapiens chromosome 1 open reading frame 124, mRNA
NCBI Official Synonym Full Names
SprT-like N-terminal domain
NCBI Official Symbol
SPRTN??[Similar Products]
NCBI Official Synonym Symbols
DVC1; PRO4323; spartan; C1orf124
??[Similar Products]
NCBI Protein Information
sprT-like domain-containing protein Spartan
UniProt Protein Name
SprT-like domain-containing protein Spartan
UniProt Synonym Protein Names
DNA damage protein targeting VCP; DVC1; Protein with SprT-like domain at the N terminus; Spartan
UniProt Gene Name
SPRTN??[Similar Products]
UniProt Synonym Gene Names
C1orf124; DVC1; DVC1; Spartan??[Similar Products]
UniProt Entry Name
SPRTN_HUMAN
NCBI Summary for C1orf124
The protein encoded by this gene may play a role in DNA repair during replication of damaged DNA. This protein recruits valosin containing protein (p97) to stalled DNA replication forks where it may prevent excessive translesional DNA synthesis and limit the number of DNA-damage induced mutations. It may also be involved in replication-related G2/M-checkpoint regulation. Deficiency of a similar protein in mouse causes chromosomal instability and progeroid phenotypes. Mutations in this gene have been associated with Ruijs-Aalfs syndrome (RJALS). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
UniProt Comments for C1orf124
SPRTN: Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis. Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Also required for localization of DNA polymerase eta (POLH) to sites of UV damage. Belongs to the Spartan family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 1q42.12-q43
Cellular Component: nuclear speck; nucleoplasm; nucleus
Molecular Function: protein binding; ubiquitin binding
Biological Process: bypass DNA synthesis; positive regulation of protein ubiquitination; response to DNA damage stimulus; response to UV
Disease: Ruijs-aalfs Syndrome
Research Articles on C1orf124
1. USP1, p21 and Spartan are translesion DNA synthesis regulators. (Review)
Precautions
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Disclaimer
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