Tumor necrosis factor receptor superfamily member 13B; TNFRSF13B; CD267; CVID; CVID2; IGAD2; RYZN; TACI; TNFRSF14B; CD 267; CD267 antigen; CVID CVID2; FLJ39942; MGC133214; MGC39952; OTTHUMP00000065442; TNFRSF 13B; TNFRSF 14B; TNFRSF13B; TNFRSF13B protein; TNFRSF14B; TR13B_HUMAN; Transmembrane activator and CAML interactor; Tumor necrosis factor receptor 13B; Tumor necrosis factor receptor superfamily member 13B

For Research Use Only. Not for use in diagnostic procedures.

Baculovirus

> 90% by SDS-PAGE

Liquid. In phosphate buffered saline (pH 7.4) containing 30% glycerol, 1mM DTT.

0.25mg/ml (determined by Absorbance at 280nm) (lot specific)

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Small volumes of TNFRSF13B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

TNFRSF13B, also known as tumor necrosis factor receptor superfamily member 13B, is a member of the tumor necrosis factor receptor superfamily. It is a trimeric cytokine receptor that binds tumor necrosis factors (TNF). It cooperates with an adaptor protein which is important in determining the outcome of the response. It has crucial roles in both innate and adaptive immunity and in cellular apoptosis process. Recombinant human TNFRSF13B, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Immunology

SDS-PAGE

45.8kDa (407aa) 25-50kDa (SDS-PAGE under reducing conditions)

TNF receptor superfamily member 13B

tumor necrosis factor receptor superfamily member 13B

Tumor necrosis factor receptor superfamily member 13B

TACI??[Similar Products]

The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.

Salzer U., et al. (2005) Nat Genet. 37:820-828.; Mohammadi J., et al. (2009) J Clin Immunol. 29:777-785.

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