Product Name
T-box transcription factor TBX19 (Tbx19), Recombinant Protein
Full Product Name
Recombinant Mouse T-box transcription factor TBX19 (Tbx19)
Product Gene Name
Tbx19 recombinant protein
[Similar Products]
Product Synonym Gene Name
Tbx19[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-446aa, full length protein
Sequence
MSELATQKAG EGTVSRLLNV VESELQAGRE KGDPTEKQLQ IILEDAPLWQ RFKEVTNEMI VTKNGRRMFP VLKISVTGLD PNAMYSLLLD FVRTDSHRWK YVNGEWVPAG KPEVSSHSCV YIHPDSPNFG AHWMKAPISF SKVKLTNKLN GGGQIMLNSL HKYEPQVHIV RVGGAHRMVM NCSFPETQFI AVTAYQNEEI TALKIKYNPF AKAFLDAKER NHLKDVPEAI SESQHVTYSH LGGWILSNPD GVCTAANSNY QYATPLPLPA PHTHHGCEHY AGLRGHRQAP YPSAYMHRNH SPSVNLIESS SNNLQVFSGP DSWTSLSSTP HASILSVPHS NGPINPGPSP YPCLWTISNG GGGPVASGSE VHASTSGTIL LGNPAVTSPS SLLPTQATTS AGVEVLGEPS LTSIAVSTWT AVASHPLPGW GGPGGAGRHS SSSLDS
3D Structure
ModBase 3D Structure for Q99ME7
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Tbx19 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Tbx19 recombinant protein
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure.
NCBI/Uniprot data below describe general gene information for Tbx19. It may not necessarily be applicable to this product.
NCBI Accession #
NP_114394.1
[Other Products]
NCBI GenBank Nucleotide #
NM_032005.4
[Other Products]
UniProt Primary Accession #
Q99ME7
[Other Products]
UniProt Secondary Accession #
Q0VBH2[Other Products]
UniProt Related Accession #
Q99ME7[Other Products]
Molecular Weight
48,037 Da
NCBI Official Full Name
T-box transcription factor TBX19
NCBI Official Synonym Full Names
T-box 19
NCBI Official Symbol
Tbx19??[Similar Products]
NCBI Official Synonym Symbols
Tpit; AU019250; D1Ertd754e
??[Similar Products]
NCBI Protein Information
T-box transcription factor TBX19
UniProt Protein Name
T-box transcription factor TBX19
UniProt Synonym Protein Names
T-box factor, pituitary
Protein Family
T-box transcription factor
UniProt Gene Name
Tbx19??[Similar Products]
UniProt Synonym Gene Names
Tpit; T-box protein 19??[Similar Products]
NCBI Summary for Tbx19
This gene encodes a member of a family of transcription factors containing a characteristic T-box DNA-binding domain. The encoded protein promotes expression of the pro-opiomelanocortin (POMC) gene, which is important for the differentiation of cells in the pituitary gland. [provided by RefSeq, Mar 2013]
UniProt Comments for Tbx19
Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters.
Research Articles on Tbx19
1. The coordinate expression of Etv1 with POMC cell differentiation and its interaction with the highly cell-restricted Tpit factor indicate that Etv1 participates in a combinatorial code for pituitary cell-specific gene expression.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
