Full Product Name
NRL Antibody
Product Synonym Names
Neural retina-specific leucine zipper protein; NRL; NRL; D14S46E
Product Gene Name
anti-NRL antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P54845
Purity/Purification
>95%
Protein G Purified
Immunogen
Recombinant Human Neural retina-specific leucine zipper protein (24-124AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at-20 degree C or-80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-NRL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-NRL antibody
Epigenetics and Nuclear Signaling
Applications Tested/Suitable for anti-NRL antibody
ELISA (EIA), Immunofluorescence (IF)
Application Notes for anti-NRL antibody
IF: 1:20-1:200
Immunofluorescence (IF) of anti-NRL antibody
Immunofluorescence staining of HepG2 cells with CSB-PA016086LA01HU at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4 degree C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
NCBI/Uniprot data below describe general gene information for NRL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006168.1
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NCBI GenBank Nucleotide #
NM_006177.4
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UniProt Primary Accession #
P54845
[Other Products]
UniProt Secondary Accession #
Q53XD0; A8MX14[Other Products]
UniProt Related Accession #
P54845[Other Products]
Molecular Weight
11,276 Da
NCBI Official Full Name
neural retina-specific leucine zipper protein isoform 1
NCBI Official Synonym Full Names
neural retina leucine zipper
NCBI Official Symbol
NRL??[Similar Products]
NCBI Official Synonym Symbols
RP27; D14S46E; NRL-MAF
??[Similar Products]
NCBI Protein Information
neural retina-specific leucine zipper protein
UniProt Protein Name
Neural retina-specific leucine zipper protein
Protein Family
Neural retina-specific leucine zipper protein
UniProt Gene Name
NRL??[Similar Products]
UniProt Synonym Gene Names
D14S46E; NRL??[Similar Products]
NCBI Summary for NRL
This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases. [provided by RefSeq, Jul 2008]
UniProt Comments for NRL
Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B (PubMed:21981118). Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 (PubMed:17335001). Binds in a sequence-specific manner to the rhodopsin promoter (PubMed:17335001).
Research Articles on NRL
1. that two photoreceptor-specific transcription factors, NRL and CRX, are master regulators of this program and are required for tumor maintenance in this subgroup
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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