Neural retina-specific leucine zipper protein; NRL; D14S46E

For Research Use Only. Not for use in diagnostic procedures.

The TFact NRL DNA-Binding ELISA detects endogenous levels of NRL.

12 x 8-Well Microstrips

Store at 4 degree C for 6 months.

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Small volumes of NRL elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9502318 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the NRL, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NRL. The ELISA analytical biochemical technique of the MBS9502318 kit is based on NRL antibody-NRL antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NRL antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NRL. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

The TFact NRL DNA-Binding ELISA detects active NRL in S-K-NAS and HEK293 Nuclear Extract. The S-K-NAS and HEK293 cells were grown 3 days in DMEM with 10% FBS and harvested for nuclear extract.

11,276 Da

neural retina leucine zipper

neural retina-specific leucine zipper protein

Neural retina-specific leucine zipper protein

D14S46E; NRL??[Similar Products]

This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases. [provided by RefSeq, Jul 2008]

NRL: Transcription factor which regulates the expression of several rod-specific genes, in cluding RHO and PDE6B. Defects in NRL are the cause of retinitis pigmentosa type 27 (RP27). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP27 inheritance is autosomal dominant. Defects in NRL are a cause of retinal degeneration autosomal recessive clumped pigment type (RDCP). A retinopathy characterized by night blindness since early childhood, consistent with a severe reduction in rod function. Color vision is normal although there is a relatively enhanced function of short-wavelength-sensitive cones in the macula. Signs of retinal degeneration and clusters of clumped pigment deposits in the peripheral fundus at the level of the retinal pigment epithelium are present (clumped pigmentary retinal degeneration). Belongs to the bZIP family.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 14q11.2-q12

Cellular Component: cytosol; nucleoplasm; nucleus

Molecular Function: DNA binding; leucine zipper domain binding; protein binding

Biological Process: positive regulation of rhodopsin gene expression; positive regulation of transcription from RNA polymerase II promoter; regulation of rhodopsin gene expression; response to stimulus; retinal rod cell development; transcription from RNA polymerase II promoter; visual perception

Disease: Retinitis Pigmentosa 27

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