Product Name
Filaggrin (FLG), Protein
Full Product Name
Filaggrin
Product Gene Name
FLG protein
[Similar Products]
Matching Pairs
Antibody: FLG (MBS2895300)
Antigen: Filaggrin (MBS2889014)
Matching Pairs
Antibody: FLG (MBS2895301)
Antigen: Filaggrin (MBS2889014)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-240aa
3D Structure
ModBase 3D Structure for P20930
Purity/Purification
>95% by SDS-PAGE
Endotoxin Level
<0.10 EU per 1 mug of the protein by the LAL method
Storage Buffer
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
Preparation and Storage
Store at -20 degree C.
Avoid repeated freezing and thawing.
Other Notes
Small volumes of FLG protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for FLG protein
Signal Transduction
Applications Tested/Suitable for FLG protein
ELISA (EIA), Western Blot (WB), Affinity Purification (AP), Protein Array
NCBI/Uniprot data below describe general gene information for FLG. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002007.1
[Other Products]
NCBI GenBank Nucleotide #
NM_002016.1
[Other Products]
UniProt Primary Accession #
P20930
[Other Products]
UniProt Secondary Accession #
Q01720; Q5T583; Q9UC71[Other Products]
UniProt Related Accession #
P20930[Other Products]
Molecular Weight
435,170 Da
NCBI Official Full Name
filaggrin
NCBI Official Synonym Full Names
filaggrin
NCBI Official Symbol
FLG??[Similar Products]
NCBI Official Synonym Symbols
ATOD2
??[Similar Products]
NCBI Protein Information
filaggrin
UniProt Protein Name
Filaggrin
UniProt Gene Name
FLG??[Similar Products]
NCBI Summary for FLG
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]
UniProt Comments for FLG
Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
Research Articles on FLG
1. This study indicates an increased susceptibility to actinic keratosis in individuals with homozygous, but not heterozygous, FLG mutations and in patients with atopic dermatitis compared to psoriasis.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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