ProTx-I
Blocker of voltage-gated sodium channels and T-type Cav
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產品名稱: ProTx-I
Blocker of voltage-gated sodium channels and T-type Cav
產品型號: 12PTX001-00100
產品展商: 其他品牌
產品文檔: 無相關文檔
簡單介紹
ProTx-I
Blocker of voltage-gated sodium channels and T-type Cav
的詳細介紹
ProTx-I
Blocker of voltage-gated sodium channels and T-type Cav
Protoxin I (ProTx-I; β-theraphotoxin-Tp1a) is a toxin that was originally isolated from the venom of Thrixopelma pruriens (Peruvian green velvet tarantula). This toxin reversibly inhibits the tetrodotoxin (TTX)-resistant channel Nav1.8(IC50 = 27 nM) and Nav1.2, Nav1.5 and Nav1.7 with IC50 values between 50 and 100 nM. Furthermore, ProTx-I shifts the voltage dependence activity of T-type Cav3.1 channels (IC50= 50 nM) without affecting the voltage dependence of inactivation. ProTx-I is a valuable tool to discriminate between Cav3.1 and Cav3.2
