Phrixotoxin-3
Selective blocker of Nav1.2
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產(chǎn)品名稱: Phrixotoxin-3
Selective blocker of Nav1.2
產(chǎn)品型號: 13PHX003-00100
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
Phrixotoxin-3
Selective blocker of Nav1.2
的詳細(xì)介紹
Phrixotoxin-3
Selective blocker of Nav1.2
Phrixotoxin-3 (PaurTx3 or Beta-theraphotoxin-Ps1a) is a valuable pharmacological tool to study voltage-gated sodium channels. Phrixotoxin-3, originally issued from the venom of the tarantula phrixotrichus auratus, has been shown to inhibit Nav1.1, Nav1.2, Nav1.3, Nav1.4 and Nav1.5 with respective IC50 values of 610 nM, 0.6 nM, 42 nM, 288 nM and 72 nM. It is thus considered as one of the most potent and almost selective modulator of Nav1.2.
